Research Achievements
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First discovery that solutions developed to protect the adult
heart during surgical repair actually damage the child's heart
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Identification of damaging components in solutions used to protect
the child's heart during cardiac surgery
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Creation of unique research model of cyanotic heart disease
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Demonstration of new methods to protect the child's heart during
surgical repair of birth defects
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Identification of key mediators responsible for resistance of
heart to injury during surgery
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First demonstration of genetic component responsible for
susceptibility to injury caused by heart attack
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Discovery that thrombopoietin, a naturally occurring protein being
developed as a pharmaceutical to increase platelet count in cancer
patients during chemotherapy, can also protect the heart against
injury during a heart attack
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Determination of molecular mechanisms underlying thrombopoietin
and erythropoietin-induced protection of the heart against injury
from ischemia-reperfusion
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First demonstration that 10Gy total body irradiation, a
potentially survivable dose in a radiation accident or
radiological terrorism event, results in injury to the
cardiovascular system
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First demonstration of delayed cardioprotection by the volatile
anesthetic isoflurane