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- First discovery that solutions developed
to protect the adult heart during surgical repair actually
damage the child's heart
- Identification of damaging components in
solutions used to protect the child's heart during cardiac
surgery
- Creation of unique research model of cyanotic
heart disease
- Demonstration of new methods to protect
the child's heart during surgical repair of birth defects
- Identification of key mediators responsible
for resistance of heart to injury during surgery
- First demonstration of genetic component
responsible for susceptibility to injury caused by heart
attack
- Discovery that thrombopoietin, a naturally
occurring protein being developed as a pharmaceutical to
increase platelet count in cancer patients during chemotherapy,
can also protect the heart against injury during a heart
attack
- Determination of molecular mechanisms underlying
thrombopoietin and erythropoietin-induced protection of
the heart against injury from ischemia-reperfusion.
- First demonstration that 10Gy total body
irradiation, a potentially survivable dose in a radiation
accident or radiological terrorism event, results in injury
to the cardiovascular system
- First demonstration of delayed cardioprotection
by the volatile anesthetic isoflurane
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